Trends in Genetics
The field of cellular senescence spans over six decades and has witnessed numerous fundamental and exciting discoveries that have transformed it from mere observations in cell culture to its recognition as an essential biological process and cell fate. It is now evident that, beyond its implications in aging, cellular senescence plays a pivotal role in various biological contexts, including acute senescence-like wound healing, development, and tissue regeneration and chronic senescence found in the pathogenesis of multiple age-related diseases such as cancer, metabolic disorders, and neurodegeneration.
In this publication, the Covarrubias lab aims to offer insights into the important role of DNA damage and genetic influences on cellular senescence phenotypes.
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