Peter Bradley, Ph.D.
Host cell invasion and host-pathogen interaction in Toxoplasma gondii
Toxoplasma gondii is an obligate intracellular parasite in the phylum Apicomplexa that causes severe central nervous system disorders of immunocompromised (AIDS/transplant/lymphoma) individuals and birth defects to congenitally infected neonates worldwide. In addition to ...(more)
David Campbell, Ph.D.,
Gene expression and variability in Kinetoplastid protozoa
My research program has two foci: the expression, maturation, and function of the spliced leader (SL) RNA in Leishmania and Trypanosoma, and genetic variability in Trypanosoma cruzi. These organisms are agents of disease in humans. Both of my studies began with the examination ...(more)
Kent Hill, Ph.D.
Parasites in Motion, Mechanism and Biology of Flagellar Motility in Trypanosomes
My laboratory is investigating flagellar motility in African trypanosomes. These protozoan parasites cause a disease that is commonly called “African Sleeping Sickness”. They are transmitted to the bloodstream of their mammalian hosts through the bite of an insect vector ...(more)
Patricia Johnson, Ph.D.
Evolution, pathogenesis & cell biology of a human parasite
Trichomonas vaginalis is a eukaryotic microbe that is responsible for the most prevalent, nonviral, sexually-transmitted infection worldwide. It is also a highly divergent, parasitic organism with biological properties that provide insight into the evolution of eukaryotic cells. Our ...(more)
Dan Ray, Ph.D.
The mitochondrial DNA of trypanosomes
The mitochondrial DNA of trypanosomes is a novel form of DNA consisting of thousands of circular DNA molecules catenated into a single enormous network termed kinetoplast DNA (kDNA). How is this network replicated and how is its replication coordinated with nuclear ...(more)
Larry Simpson, Ph.D.
Molecular biology of parasitic protozoa
I am interested in the molecular biology of parasitic protozoa known as trypanosomes or kinetoplastid protozoa. In particular, we are investigating a novel type of RNA modification phenomenon termed “RNA editing”, that occurs in the single mitochondrion. mRNA ...(more)