Douglas Black, Ph.D.
The regulation of pre-mRNA splicing in neurons
Our lab is interested in how the process of pre-mRNA splicing is regulated in differentiated cells, particularly neurons. Alternative splicing is a fundamental mode of genetic control in eucaryotes where it is frequently used for the generation of multiple mRNAs and proteins from a single ...(more)
Genhong Cheng, Ph.D.
Host Immune and Inflammatory Responses to Infections, Cancers and Metabolic Challenges
Research in Dr. Cheng’s laboratory is aimed at the process of innate and adaptive immune responses in host defense against bacterial and viral infections as well as tumor challenges ...(more)
C. Fred Fox, Ph.D.
In bacteria and Archea, biological oxidations are frequently mediated via enzymes directly linked to the electron transport system. Efforts are being made to isolate oxidoreductases that catalyze steps in denitrification in bacteria or Archea, concentrating on the nitric oxide reductase ...(more)
Elissa Hallem, Ph.D.
Our lab is interested in the interactions between parasitic nematodes and their hosts. Many parasites actively locate their hosts using chemosensory cues. We are interested in the neural circuits and signaling pathways that underlie host–seeking ...(more)
Ron Kaback, Ph.D.
Molecular Biology of Membrane Transport
The lactose permease of Escherichia coli (LacY), a particularly well-studied paradigm for ion gradient driven active transport proteins, is solely responsible for all translocation reactions catalyzed by the galactoside transport system in E. coli. Like many active transport proteins ...(more)
Aldons Lusis, Ph.D.
Almost all common diseases, from diabetes to schizophrenia to arthritis to cancer, are complex. That is, these disorders are due to interactions of multiple genetic and environmental factors. Although the medical research community has been very successful in identifying the ...(more)
April Pyle, Ph.D.
Human Embryonic Stem Cell Survival, Transformation and Cell Fate Decisions
Human embryonic stem cells (hESCs) have enormous potential for cellular therapy and also for gaining an understanding of human development. Our lab is interested in understanding how hESCs have the ability to both self-renew (give rise to a new stem cell) and differentiate into ...(more)
Fuyuhiko Tamanoi, Ph.D.
Signal Transduction, Protein Lipidation and Prenyltransferase Inhibitors, Nanodelivery of Anticancer Drugs
Signal Transduction: The Ras superfamily G-proteins function as a molecular switch to regulate signaling pathways. Currently, we are investigating a unique subfamily called Rheb G-protein ...(more)
Bernadine Wisnieski, Ph.D.
Structure-Function Relationships of Cytotoxic Proteins One goal is to understand the mechanism by which tumor necrosis factors (TNF-alpha and TNF-beta) elicit a variety of cell-type specific effects. Our discovery that these cytokines exhibit ion channel activity has sparked an ...(more)
Owen Witte, M.D.
Growth Regulation of Hematopoietic and Epithelial Cancers and the Immune Response
The Role of the BCR-ABL Oncogene in Leukemias. Human chronic myelogenous leukemia (CML) is associated with the Philadelphia chromosome, which produces the BCR-ABL tyrosine kinase oncogene. Our laboratory demonstrated that this kinase is critical for the leukemic ...(more)
Yi Xing, Ph.D.
Genomics and Systems Biology of RNA Regulation
The long-term goal of our research is to elucidate how genomic and environmental variation of RNA regulatory networks impacts phenotypic traits and diseases. We are a hybrid computational and experimental lab. We combine genomic, bioinformatic, molecular, and network approaches to ...(more)