Recent Publications

Updated on January 20., 2011

113) Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K. Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species..Science.2010 Dec 23. [Epub ahead of print]

112) Su-Yang Liu, David Jesse Sanchez and Genhong Cheng New developments in the induction and antiviral effectors of type I interferon. Curr Opin. Immunol. 2010 Nov 29. [Epub ahead of print]

111) Jihuan Fu, Yanbao Xiong, Youli Xu, Genhong Cheng, Hong Tang MDA5 is SUMOylated by PIAS2_ in the upregulation of Type I interferon signaling.  Molecular Immunology 48:415-422 2011

110) Eric Schopf, Yang Liu, Jane C. Deng, Siyin Yang, Genhong Cheng and Yong Chen Mycobacterium tuberculosis detection via rolling circle amplification Anal. Methods, 2011, Advance Article DOI: 10.1039/C0AY00529K

109) Shankar S. Iyer, Amir Ali Ghaffari and Genhong Cheng LPS mediated IL-10 transcriptional regulation requires sequential induction of Type I Interferons and Interleukin-27 in macrophages. J Immunol. 185(11):6599-607.  2010 .PMID: 21041726

108) Bahram Razani and Genhong Cheng NF-κB: Much Learned, Much to Learn, Science Signaling, 2010 .PMID: 20823402

  • 107) Anurupa Dev, Shankar Iyer, Bahram Razani, Genhong Cheng, NF-kB and Innate Immunity,  Curr Top Microbiol Immunol. 2010 , PMID: 20848362

106) Cheng G, Liu Y, Tang H. Vaccination is one of the most significant inventions in medical science. Sci China Life Sci. 2010 Feb;53(2):157-8. PMID: 20596821

105) Wang Y, Zhang P, Liu Y, Cheng G. TRAF-mediated regulation of immune and inflammatory responses Sci China Life Sci. 2010 Feb;53(2):159-68. Epub 2010 Mar 7. PMID: 20596822

104) Bahram Razani, Brian Zarnegar, Anders J. Ytterberg, Travis Shiba, Paul Dempsey, Carl F. Ware, Joseph A. Loo, Genhong Cheng Negative Feedback in Non-canonical NF-kB Signaling Modulates NIK Stability Through IKKα-mediated Phosphorylation Science Signaling, May 25;3(123):ra41., 2010, PMID: 20501937

103) Chin AI, Miyahira AK, Covarrubias A, Teague J, Guo B, Dempsey PW, Cheng G. Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res. 1;70(7):2595-603. 2010.PMID: 20233880

102) Chao Zheng, Venkataraman Kabaleeswaran, Yaya Wang, Genhong Cheng, and Hao Wu Crystal structures of the TRAF2: cIAP2 and the TRAF1:TRAF2: cIAP2 complexes – affinity, specificity and regulation Molecular Cell, 38(1):101-13. 2010. PMID: 203850, PMCID: PMC2855162

101) John S. Cho, Eric M. Pietras2, Nairy C. Garcia1, Romela Irene Ramos1, David M. Farzam1, Holly R. Monroe1, Julie E. Magorien1, Andrew Blauvelt, Jay K. Kolls, Ambrose L. Cheung, Genhong Cheng, Robert L. Modlin1,2, and Lloyd S. Miller IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection J Clin Invest., doi: 10.1172/JCI40891. 2010, [Epub ahead of print]PMID: 20364087, PMCID: PMC2860944

100) Montoya,D , Cruz2, D., Teles, R., Lee, DJ., Ochoa, MT. Krutzik, SR., Chun, R., Schenk, M., Zhang, X., Ferguson, BG.,Burdick, AE., Rea, TH., Hewison, M., Adams, J., Cheng G, and Modlin, RL., Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. 6(4):343-53, 2009, PMID: 19837374, PMCID: PMC2764558

99) Philip T. Liu, Mirjam Schenk, Valencia P. Walker, Paul W. Dempsey, Melissa Kanchanapoomi, Matthew Wheelwright, Aria Vazirnia, Xiaoran Zhang, Andreas Steinmeyer, Ulrich Zugel, Bruce W. Hollis, Genhong Cheng, Robert L. Modlin Convergence of IL-1b and VDR Activation Pathways in Human TLR2/1-Induced Antimicrobial Responses. Plos One, 4(6):e5810, 2009, PMID: 19503839, PMCID: PMC2686169

98) Subramanian A, Guo B, Marsden MD, Galic Z, Kitchen S, Kacena A, Brown HJ, Cheng G, Zack JA. Macrophage differentiation from embryoid bodies derived from human embryonic stem cells. J Stem Cells. 2009;4(1):29-45. doi: jsc.2009.4.1.29.PMID: 20498689

97) Shahangian A, Chow EK, Tian X, Kang JR, Ghaffari A, Liu SY, Belperio JA, Cheng G, Deng JC. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest. 2009 Jul;119(7):1910-20.PMID: 19487810, PMCID: PMC2701856

96) Hwang S, Kim KS, Flano E, Wu TT, Tong LM, Park AN, Song MJ, Sanchez DJ, O'Connell RM, Cheng G, Sun R Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response. Cell Host Microbe. 2009 Feb 19;5(2):166-78, PMID: 19218087, PMCID: PMC2749518

95) Miyahira, AK, Shahangian, A., Hwang, S., Sun, R. Cheng G. TANK-binding kinase-1 plays an important role during in vitro and in vivo type I interferon responses to DNA virus infections. J Immunol. 2009 Feb 15;182(4):2248-57.

94) Zarnegar BJ, Wang Y., Mahoney DJ, Dempsey PD, Cheung HH, He J, Shiba T, Yang X., Yeh WC, Mak TW, Korneluk RG, and Cheng G. "Noncanonical NF-κB Activation Requires the Coordinated Assembly of the cIAP1/2-NIK Regulatory Complex by TRAF2 and TRAF3". Nature Immunology, 2008 Dec;9(12):1371-8. Epub 2008 Nov 9. PMCID: PMC2676931

93) Zheng D., Chen G., Guo B., Cheng G, and Tang H. PLP2, a potent deubiquitinase from murine hepatitis virus, can strongly inhibit cellular type I interferon production. Cell Res. 11:1105-13. PMID: 18957937, 2008

92) Cheng LS., Hwang S., Huang TH, Sheu TC, Sun R., Morrison SL, Cheng G, and Shahangian A. Antibody-fused interferons as an effective approach to enhance target specificity and antiviral efficacy of type I interferons Cell Res. advance online publication, November 11, 2008; doi:10.1038/cr.2008.304

91) Pietras EM, Cheng G., A New TRADDition in intracellular antiviral signaling. Science Signaling 2008 Jul 29;1(30):pe36

90) Tricker E, Cheng G. With a little help from my friends: modulation of phagocytosis through TLR activation. Cell Res. 2008 Jul;18(7):711-2.

89) Zarnegar, B., Yamazak S. He JQ, Cheng G. Control of Canonical NF-κB Activation through the NIK-IKK-Complex Pathway. PNAS, 2008 Feb 21; [Epub ahead of print], PMID: 18292232.

88) Chow, EKH., Pierstorff, E., Cheng, G., and Ho, D. Copolymeric Nanofilm Platform for Controlled and Localized Therapeutic Delivery ACS Nano, 2(1), 33-40, 2008.

87) Zhai Y, Qiao B, Shen XD, Gao F, Busuttil RW, Cheng G, Platt JL, Volk HD, Kupiec-Weglinski JW. Evidence for the Pivotal Role of Endogenous Toll-Like Receptor 4 Ligands in Liver Ischemia and Reperfusion Injury. Transplantation. 85(7):1016-1022, 2008.

86) Velázquez, P, Wei, B, McPherson M, Mendoza, LM, Nguyen, SL, Turovskaya, O, Kronenberg, M, Huang, TT, Schrage, M, Lobato, LN, Fujiwara, D, Brewer, S, Arditi, M, Cheng, G, Sartor, RB, Newberry, RD, Braun, J. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol. 180(7):4629-38, 2008

85) Wong PK., Yu, F., Shahangian, A., Cheng, G., Sun, R., and Ho, CM. Closed-loop Control of Cellular Functions By using a Stochastic Search Algorithm PNAS, 105:5105-5110, 2008

84) Razani, B., Shahangian, A., Guo, B. and Cheng, G,. Biological Impact of Type I Interferon Induction pathways beyond their Anti-virus Activity. In: Cellular Signaling and Innate Immune Responses to RNA Virus infections. Allan Brasier, Stan Lemon, and Adolfo García-Sastre, Editors. ASM Press. 2008.

83) Guo B, Chang EY, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. Journal of Clinical Investigation, 118:1680-1690. 2008

82) Pietras EM, Cheng G., New tricks for old NODs. Genome Biol. 9(4):217, 2008, PMID: 18466630

81) Sanchez DJ, Miranda D Jr, Arumugaswami V, Hwang S, Singer AE, Senaati A, Shahangian A, Song MJ, Sun R, Cheng G. A Repetitive Region of Gamma-herpesvirus Genomic DNA Is a Ligand for Induction of Type I Interferon. J Virol. 2008 Mar;82(5):2208-17. Epub 2007 Dec 12

80) Oganesyan, G., Saha, SK., Pietras, EM., Guo, B., Miyahira, AP.,Zarnegar, B., and Cheng, G. IRF3-dependent Type I interferon response in B cells regulates CpG-mediated antibody production. J Biol Chem. 2008 Jan 11;283(2):802-8. Epub 2007 Oct 9. PMID: 17925397.

79) Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL. LILRA2 Activation Inhibits Dendritic Cell Differentiation and Antigen Presentation to T Cells. J Immunol.179(12):8128-36. PMID: 18056355. 2007.

78) Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL. LILRA2 Activation Inhibits Dendritic Cell Differentiation and Antigen Presentation to T Cells. J Immunol.179(12):8128-36. PMID: 18056355. 2007.

77) Chow, EKH., Chu, B., Cheng G., Tai, YC., Pierstorff, P., and Ho., D. Copolymer-mediated Fabrication of Versatile Electro-Active and Inflammation Attenuating Substrates for Biological Interrogation. NANO: Brief Reports and Reviews 2 (6): 351-359, 2007

76) Kayagaki, N., Phung, Q., Chan, S., Chaudhari R, Quan, C., O'Rourke, KM., Eby, M., Pietras, E, Cheng, G., Bazan, JF., Zhang, Z., Arnott, D., Dixit, VM.. DUBA: A Deubiquitinase That Regulates Type I Interferon Production. Science. 2007 Dec 7;318(5856):1628-32. Epub 2007 Nov 8. PMID: 17991829.

75) Miller, LS., Pietras, EM., Uricchio, LH., Hirano, K., Rao, S., Lin, H., O'Connell, RM., Iwakura, Y., Ambrose L. Cheung, AL., Cheng G., Modlin, RL. Inflammasome-mediated production of IL-1ß is required for neutrophil recruitment against Staphylococcus aureus in vivo. J. Immunol., 179(10):6933-42, 2007

74) Chang, EY., Guo B, Doyle, S. Cheng G. Involvement of type I interferon production and signaling pathway in lipopolysaccharide-induced IL-10 production. J. Immunol., 178(11):6705-9. 2007.

73) Chow EK, Razani B, Cheng G. Innate immune system regulation of nuclear hormone receptors in metabolic diseases. J Leukoc Biol. 82(2):187-95, 2007. Epub Feb 21, 2007; PMID: 17314330.

72) Guo B, Cheng G. Modulation of the interferon antiviral response by the TBK1/IKKI adaptor protein tank. J Biol Chem. 282(16):11817-26, 2007. Epub Feb 26, 2007. PMID: 17327220.

71) O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D. MicroRNA-155 is induced during the macrophage inflammatory response. PNAS, 104(5):1604-9, 2007. Epub 2007 Jan 22. PMID: 17242365.

70) He JQ, Oganesyan G, Saha SK, Zarnegar B, Cheng G. TRAF3 and its biological function. Adv Exp Med Biol. 597:48-59, 2007.

69) He JQ, Saha SK, Kang JR, Zarnegar B, Cheng G. Specificity of TRAF3 in its negative regulation of the noncanonical NF-κB pathway. J Biol Chem. 282(6):3688-94, 2007 Dec 11; [Epub ahead of print] PMID: 17158868, 2006

68) He, JQ., Zarnegar, B., Yamazaki, S., Oganesyan, G., Saha, SK., Doyle, S., Dempsey, P., and Cheng, G. Rescue of TRAF3 null mice by p100 NF-κB deficiency. J Exp Med., 203 (11):2413-2418, 2006. Epub 2006 Oct 2. PMID: 17015635.

67) Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. A role for IRF3-dependent RXRα repression in hepatotoxicity associated with viral infections. J Exp Med. 203(12):2589-602, 2006. Epub 2006 Oct 30. PMID: 17074929

66) Pietras, EM., Saha, SK. and Cheng, G. The Interferon Response to bacterial and viral infections. Journal of Endotoxin Research, 12(4):246-50, 2006.

65) Saha, SK., Pietras, EM., He, JQ., Kang, JR., Liu, SY., Oganesyan, G., Shahangian, A., Zarnegar, B., Shiba TL., and Cheng, G. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 25:3257-3263, 2006

64) Saha, SK and Cheng, G. TRAF3: A New Regulator of Type I Interferons. Cell Cycle. 5 (8):804-807, 2006

63) Renn, CN, Sanchez, DJ, Ochoa, MT, Legaspi, AJ, Oh, CK, Liu, PT, Krutzik, SR, Sieling, PA, Cheng, G, Modlin, RL. TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response J Immunol. 177(1):298-305, 2006

62) Miller, LS., O'Connell, RM., Gutierrez, MA., Pietras, EM., Shahangian, A., Gross, CE., Thirumala, A., Cheung, AL., Cheng , G. , Modlin, RL. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus Immunity, 24:79-91, 2006.

61) Oganesyan, G., Saha, SK, Guo, B., He, J., Shahangian, A., Zarnegar B., Perry, AK., Cheng, G. Critical role of TRAF3 in the Toll-like receptor-dependent and independent antiviral response. Nature, 439:208-211, 2006.

60) Chow, EK., O'Connell, RM, Schilling, S., , Wang, XF., Fu, XY., and Cheng , G. TLR Agonists Regulate PDGF-B Production and Cell Proliferation through TGF-beta/Type I IFN Crosstalk EMBO J. 24:4071-4081, 2005.

59) erry, AK., Chen, G., Zheng, DH., Tang, H., Cheng, G. The host type I interferon response to viral and bacterial infections. Cell Res. 15:407-422, 2005.

58) Shen, DX., Ke, B., Zhai, Y., Gao, F., Busuttil, RW., Cheng, G., Kupiec-Weglinski, JW. Toll-Like Receptor and Heme Oxygenase-1 Signaling in Hepatic Ischemia/Reperfusion Injury. Am J Transplant. 5:1793-800, 2005

57) O'Connell, RM, Saha, SK and Cheng, G. Combating bacterial pathogens through host defense gene programs. Current Immunology Reviews, 1:43-54, 2005.

56) Chin,AI., Dempsey, PW. And Cheng, G. Rip2: a key molecule that regulates both innate and acquired immunity. Current Medicinal Chemistry, 4:35-42, 2005.

55) O'Connell, RM, Vaidya, VA, Perry, AK, Saha, SK, Dempsey, PW., and Cheng, G. Immune activation of type I IFNs by Listeria monocytogenes occurs independent of TLR4, TLR2 and receptor interacting protein 2 but involves tank-binding kinase 1. J. Immunol., 174:1602-1607, 2005

54) Liu, B., Wong, KA., Getman, C., Gao, J., Teitell, M., Cheng, G., Wu., H., and Shuai K. A Negative Regulation of NF-kB Signaling by PIAS1. Mol. Cell. Biol. 25:1113-23, 2005.

53) Jazirehi, AR., Huerta-Yepez, S., Cheng, G. and Bonavida, B. Rituximab B signaling NF- kB (chimeric anti-CD20 mAb) inhibits the constitute NIK/IKK/I pathway in non-Hodgkin's lymphoma (NHL) B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Research, 65:264-276, 2005

52) Ni, CZ, Oganesyan, G., Welsh, K., Zhu, X., Reed, JC., Satterthwait, AC., Cheng, G., and Ely, KR. Key Molecular Contacts Promote Recognition of BAFF Receptor by TNF Receptor-Associated Factor 3: Implications for Intracellular Signaling Regulation. J. Immunol., 173: 7394-7400, 2004.

51) Zhai, Y., Shen, X., O'Connell, R., Gao, F., Lassman, C., Busuttil, RW., Cheng, G., Kupiec-Weglinski, JW. TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway. J. Immunol., 173: 7115-7119, 2004.

50) Modlin, RL. And Cheng, G. From plankton to pathogen recognition. Nature Medcine, 10:1173-1174, 2004.

49) Joseph, S.B., Bradley, M.N., Castrillo, A., Bruhn, K.W., Mak, P.A., Liming, P., Hogenesch, J., O'Connell, RM., Cheng, G., Saez, E., Miller, J.F. and Tontonoz, P. LXR-dependent gene expression is important for macrophage survival and the innate immune response to bacterial pathogens. Cell, 119: 299-309, 2004.

48) O'Connell, RM, Saha, SK., Vaidya SA, Bruhn, KW., Gustavo A. Miranda, GA., Brian Zarnegar, B., Perry, AK., Nguyen, B., Lane, TF., Taniguchi, T., Miller, JF., and Cheng, G. Type I Interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med., 200:437-445, 2004.

47) Perry, AK., Chow, EK., Goodnough, JB.,, Yeh, WC., and Cheng, G. Differential Requirement for TANK-Binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection. J Exp Med., 199:1651-1658, 2004.

46) Huerta-Yepez, S., Vega, M., Jazirehi, A., Garban., H., Hongo, F., Cheng, G., and Bonavida, B. Nitric oxide sensitize prostate B andcarcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kB inhibition of Bcl-xL expression. Oncogene, 23:4993-5003, 2004.

45) Zarnegar B., He, J., Oganesyan, G., Hoffmann, A., Baltimore, D. and Cheng G. Unique CD40-mediated biological program in B-cell activation requires B activation pathways both type 1 and type 2 NF-kB. Proc. Natl. Acad. Sci. USA, 101:8108-8113, 2004.

44) Doyle, S. E., O'Connell, R. M., Miranda, G. A., Vaidya, S. A., Chow, E. K., Liu, P. T., Suzuki, S., Suzuki, N., Modlin, R. L., Yeh, W. -C., Lane, F. T. and Cheng, G. Toll-like Receptors Induce a Phagocytic Gene Program through p38. J Exp Med., 199:81-90. 2004.

43) Dadgostar, H., Doyle, S. E., Shahangian, A., Garcia, D. E., and Cheng, G. T3JAM, a novel Tumor Necrosis Factor Receptor-Associated Factor 3-interacting protein that allows Tumor Necrosis Factor Receptor-Associated Factor 3 to activate JNK. FEBS L, 553:403-40, 2003.

42) Dempsey PW, Vaidya SA, and Cheng G. The Art of War: Innate and Adaptive Immune Responses. Cell Mol Life Sci 60:2604-21, 2003.

41) Castrillo, A., Joseph SB., Vaidya, A., Haberland, M., Fogelman AM., Cheng, G., and Tontonoz, P. Crosstalk Between LXR and Toll-like Receptor Signaling Mediated Bacterial and Viral Antagonism of Cholesterol Metabolism. Molecular Cell 12:805-816, 2003.

40) Vaidya, S. A. and Cheng, G. Toll-like Receptors and Innate Antiviral Responses. Curr Opin Immunol 15:402-407, 2003.

39) Brown, HJ., Song, MJ, Deng, H., Wu, TT., Cheng, G., Sun, R. NF-kappaB Inhibits Gammaherpesvirus Lytic Replication. J Virol. 77, 8532-8540, 2003.


38) Dempsey, P.W., Doyle, S.E., He, J., and Cheng, G. The Signaling Adaptors and Pathways Activated by TNF Superfamily, TRAFs and Death Domains. Cytokines and Growth Factors Review. 14:193-209, 2003.

37) hen, MC, Hwang, MJ, Chou, YC, Chen, WH, Cheng, G, Nakano, H, Luh, TY, Mai, SC, Hsieh, SL. The role of ASK1 in Lymphotoxin-beta receptor-mediated cell death. J Biol Chem. 278:16073-81, 2003.

36) Doyle, S. E., O'Connell, R., Vaidya, S. A., Chow, E. K., Yee, K., Cheng, G. TLR3 mediates a more potent antiviral response than TLR4. J. Immunol., 170:3565-71, 2003.

35) Ronni, T. Agarwal, V., Haykinson, M., Haberland, M.E., Cheng, G., Smale, S. T. Common Interaction Surfaces of Toll-Like Receptor 4 Cytoplasmic Domain Stimulate Multiple Nuclear Targets. Mol. Cell. Biol. 23:2543-2555, 2003.

34) Doyle, S. E., Vaidya, S. A., O'Connell, R., Dadgostar, H., Dempsey, P. W., Wu, T. T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., Cheng, G. IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program. Immunity 17:251-263, 2002.

33) Li, C., Ni, C. Z. , Havert, M., Cabezas, E., He, J., Kaiser, D., Reed, J. C., Satterthwait, A. C., Cheng, G. and Ely, K. R. Downstream Regulator TANK Binds to the CD40 Recognition Site on TRAF3. Structure 10:403-411, 2002.

32) Cheng, G. and Schoenberger, S. P. CD40 Signaling and Autoimmunity. Curr Dir Autoimmun 5:51-61, 2002.

31) Chin, A. I., Dempsey, P. W., Bruhn, K., Miller, J. F., Xu, Y., and Cheng, G. Involvement of Receptor Interacting Protein 2 in Innate and Adaptive Immune Responses. Nature 416:190-194, 2002.

30) Dadgostar, H., Zarnegar, B., Hoffmann, A., Qin, X. F., Truong, U., Rao, G., Baltimore, D. and Cheng, G. Cooperation of Multiple Signaling Pathways in CD40-Regulated Gene Expression in B Lymphocytes. Proc. Natl. Acad. Sci. USA, 99: 1497-1502, 2002.

29) Wang, Y, Kelly, C. G., Karttunen, J. T., Whittall, T., Lehner, P. J., Duncan, L., MacAry, P., Younson, J. S., Singh, M., Oehlmann, W., Cheng, G., Bergmeier, L. and Lehner. T. CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines. Immunity 15:971-83, 2001.

28) Kwan, R., Burnside, J., Kurosaki, T. and Cheng, G. MEKK1 Is Essential for DT40 Cell Apoptosis in Response to Microtubule Disruption. Mol. Cell. Biol. 21:7183-7190, 2001.

27) Bleharski, J. R., Niazi K. R., Sieling, P. A., Cheng, G., and Modlin, R. L. Signaling lymphocytic activation molecule (SLAM) is expressed on CD40L-activated dendritic cells and directly augments production of inflammatory cytokines. J. Immunol., 167:3174-81, 2001.

26) Mori, M., Fujii, M., Cheng, G., Ikeda, S., Yamasaki, Y., Yamada, Y., Tomonaga, M., and Yamamoto, N. Human T-cell leukemia virus type I Tax protein induces the expression of anti-apoptotic gene bcl-XL in human T B and c-AMP pesponsive element binding proteincells through nuclear factor- pathways. Virus Genes 22:279-287, 2001.

25) Chamorro, M., Czar, M. J., Debnath, J, Cheng, G., Lenardo, M. J., Varmus, H. E., and Schwartzberg, P. L. Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol. 2:3, 2001.

24) Fischbein, MP, Ardehali, A., Yun, J. Schoenberger, S., Laks, H., Irie, Y., Dempsey, P., Cheng, G., Fishbein MC, and Bonavida, B. CD40 signaling replaces CD4 lymphocytes and its blocking prevents chronic rejection of heart transplants. J. Immunol. 165: 7316-22, 2000.

23) Cheng, Q., Lee, H. H., Ying Li, Parks, T., and Cheng, G. Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-kB inhibition. Oncogene 19:4936-4940, 2000.

22) Jewett, A., Hume, W.R., Lee, H., Cheng, G., and Shi, W. Induction of apoptotic cell death in peripheral blood mononuclear cells and polymorphonuclear cells by oral bacterium F. nucleatum. Infection and Immunity 68:1893-1898, 2000.

21) Dadgostar, H., and Cheng, G. Membrane localization of TRAF 3 enables JNK activation. J. Biol. Chem. 275:2539-2544, 2000.

20) Lee, H., Dadgostar, H., Shu, J., Cheng, Q., and Cheng, G. The NF-kB signal transduction pathway is essential for CD40-mediated up-regulation of the Bcl-x and Bfl-1 genes and B cell survival. Proc. Natl. Acad. Sci. USA 96:9136-9141, 1999.

19) Chin, A., Shu, J., Shi, C.S., Yao, Z. B., Kehrl, J. H., and Cheng, G. TANK Potentiates Tumor Necrosis Factor Receptor-Associated Factor-Mediated c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase Activation through the Germinal Center Kinase Pathway. Mol. Cell. Biol. 19:6665-6672, 1999.

18) Lee, H., Demsey, P., Parks, T., Zhu, X., Baltimore, D. and Cheng, G. Specificities of CD40 Signaling: involvement of TRAF2 in CD40-induced NF-kB activation and intercellular adhesion molecule-1 up-regulation. Proc. Natl. Acad. Sci. USA 96:1421-1426, 1999.

17) Dadgostar, H., and Cheng, G. An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-kappaB activation but is dispensable for c Jun N-terminal kinase signaling. J. Biol. Chem. 273: 24775-24780, 1998.

16) Posern, G., Zheng, J., Knudsen, B. S., Muller, K. B., Voss, J., Shishido, T., Cowburn, D., Cheng, G., Wang, B., Kruh, G. D., Burrell, S. K., Jacobson, C. A., Lenz, D. M., Zamborelli, T. J., Adermann, K., Hanafusa, H., and Feller, S. M. Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SOS and C3G. Oncogene 16:1903-1912, 1998.

15) Brodeur, S. R., Cheng, G., Baltimore, D., and Thorley-Lawson, D. A. BLocalization of the major NF- activation site and the sole TRAF3 binding site of LMP-1 defines two distinct signalling motifs. J. Biol. Chem. 272: 19777-19784, 1997.

14) Rao, G., Rekhtman, N., Cheng, G., Krasikov, T., and Skoultchi, A. I. Deregulation expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation. Oncogene 14:123-131, 1997.

13) Xu, Y., Cheng, G., and Baltimore, D. Targeted disruption of TRAF3 leads to postnatal lethality and defective T dependent immune responses. Immunity 5: 407-415, 1996.

12) Cheng, G., and Baltimore D. TANK, a novel TRAF2 domain of TNF and B activation. CD40L-mediated NF-kB Genes Devel. 10:963 973, 1996.

11) Sirotkin, A. M., Edelmann, W., Cheng, G., Klein Szanto, A., Kucherlapati, R., and Skoultchi, A., Mice develop normally without the Hl° linker histone. Proc. Natl. Acad. Sci. USA 92:6434 6438, 1995.

10) Alexandropoulos, K., Cheng. G., and Baltimore, D. Proline rich sequences that bind to Src homology 3 domains with individual specificities. Proc. Natl. Acad. Sci. USA 92:3110 3114, 1995.

9) Baltimore, D., Ren, R., Cheng, G., Alexandropoulos, K., and Cicchetti P. A nuclear tyrosine kinase becomes a cytoplasmic oncogene. Ann N Y Acad Sci 758:339-44, 1995

8) Cheng, G., Cleary, A. M., Ye, Z. S., Hong, D. I., Lederman, S., and Baltimore, D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267:1494-1498, 1995.

7) Saksela K., Cheng, G., and Baltimore, D. Proline-rich (PXXP) motifs in HIV Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for downregulation of CD4." EMBO J. 14:484 491, 1995.

6) Cheng, G., Ye, Z. S., and Baltimore, D. Binding of Bruton's tyrosine kinase (Btk) to Fyn, Lyn or Hck through an SH3 mediated interaction. Proc. Natl. Acad. Sci. USA 91:8152 8155, 1994.

5) Krimer D. B., Cheng, G., and Skoultchi, A. I. Induction of H3.3 replacement histone mRNAs during the precommitment period of murine erythroleukemia cell differentiation. Nucleic Acids Res. 21(12):2873 2879, 1993.

4) Schubart, U. K., Xu, J., Fan, W., Cheng, G., Goldstein, H., Alpini, G., Shafritz, D. A., Amat, J. A., Farooq, M., Norton, W. T., Owen, T. A., Lian, J. B., and Stein, G. S. Widespread differentiation stage specific expression of the gene encoding phosphoprotein p19 (metablastin) in mammalian cells. Differentiation 51(1):21 32,

3) Cheng,G., Nandi, A., Clerk, S., and Skoultchi, A. I. Different 3'-end processing procedures in ¬two independently regulated mRNAs from a single H1 histone gene. Proc. Natl. Acad. Sci. USA 86:7002 7006, 1989.

2) Cheng, G., and Skoultchi, A. I. Rapid induction of polyadenylated H1 histone mRNAs in mouse erythroleukemia cells is regulated by c myc. Mol. Cell. Biol. 9:2332 2340, 1989.

1) Lachman, H. M., Cheng, G., and Skoultchi, A. I. Transfection of mouse erythroleukemia cells with myc sequences changes the rate of induced commitment to differentiate. Proc. Natl. Acad. Sci. USA 83:6380 6484, 1986.